IHC 30 th gw


At the late fetal stage, subventricular and intermediate transitional zones, subplate, and cortical plate demonstrate more uniform  ALDH1L1-immunoreactivity (Kharlamova et al., 2024). 



At the late fetal period, intermediate  and subplate transitional zones (developing white matter in perinatal fetuses and newborns), which were difficult to separate from each other in the late fetuses demonstrated GFAP-immunoreactive cells of astrocyte cytomorphology. The ventricular layer was GFAP-immunoreactive and its medial part was still located around the zone with several GFAP-immunoreactive fibers and densely placed small cells. The difference between the medial and lateral inner part of subventricular zone smoothed out. The outer layer of the subventricular zone of densely-packed cells showed less immunoreactive elements than the inner part of this zone and ventricular zone. No GFAP-immunoreactive cells were shown in the cortical plate of the late fetuses (Kharlamova et al., 2024).


In the occipital lobe, NeuN immunoreactivity predominated in the banks of the sulci and in the lingual gyrus (gyrus lingualisgyrus occipitotemporalis medialis) . In the gyrus, labeled cells were presented in all cortical plate layers. Inside the sulci, labeling gradually weakened. Near the calcarine sulcus fundus, NeuN-immunopositive cells were preserved in layer VI. Inside the parietooccipital sulcus, immunoreactivity was lower. The NeuN immunoreactivity of the subplate decreased in the late fetal period in both sulci (Godovalova et al., 2024).